![]() ![]() In addition, another trial found that a MDI (with spacer) had a lower required dose for clinical result compared to a nebulizer (see Clark, et al. Two advantages attributed to nebulizers, compared to MDIs with spacers (inhalers), are their ability to deliver larger dosages at a faster rate, especially in acute asthma however, recent data suggests actual lung deposition rates are the same. They found this practice could vary droplet size 10-fold or more by changing from an inefficient nebulizer system to a highly efficient one. The European Respiratory Society highlighted a risk relating to droplet size reproducibility caused by selling nebulizer devices separately from nebulized solution. For COPD, especially when assessing exacerbations or lung attacks, there is no evidence to indicate that MDI (with a spacer) delivered medicine is more effective than administration of the same medicine with a nebulizer. Those findings refer specifically to the treatment of asthma and not to the efficacy of nebulisers generally, as for COPD for example. An MDI with a spacer may offer advantages to children who have acute asthma. Recent evidence shows that nebulizers are no more effective than metered-dose inhalers (MDIs) with spacers. The European Respiratory Society acknowledge that although nebulizers are used in hospitals and at home they suggest much of this use may not be evidence-based. ![]() Various asthma guidelines, such as the Global Initiative for Asthma Guidelines, the British Guidelines on the management of Asthma, The Canadian Pediatric Asthma Consensus Guidelines, and United States Guidelines for Diagnosis and Treatment of Asthma each recommend metered dose inhalers in place of nebulizer-delivered therapies.
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